Detailed information of TA system TA286709

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2058588..2058895
• Replicon: chromosome
• Accession: NZ_LR134086
• Organism: Staphylococcus aureus strain NCTC13142

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ELZ49_RS10500
• Protein ID: WP_011447039.1
• Coordinates: 2058719..2058895 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2058588..2058727 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELZ49_RS10455	2053927..2054187	+	261	WP_001791826.1	hypothetical protein	-
ELZ49_RS10460	2054240..2054590	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
ELZ49_RS10465	2055275..2055724	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
ELZ49_RS10470	2055819..2056154	-	336	Protein_1945	SH3 domain-containing protein	-
ELZ49_RS10480	2056804..2057295	-	492	WP_000919349.1	staphylokinase	-
ELZ49_RS10485	2057486..2058241	-	756	WP_000861038.1	CHAP domain-containing protein	-
ELZ49_RS10490	2058253..2058507	-	255	WP_000611512.1	phage holin	-
ELZ49_RS10495	2058559..2058666	+	108	WP_001791821.1	hypothetical protein	-
-	2058588..2058727	+	140	NuclAT_1	-	Antitoxin
-	2058588..2058727	+	140	NuclAT_1	-	Antitoxin
-	2058588..2058727	+	140	NuclAT_1	-	Antitoxin
-	2058588..2058727	+	140	NuclAT_1	-	Antitoxin
ELZ49_RS10500	2058719..2058895	-	177	WP_011447039.1	putative holin-like toxin	Toxin
ELZ49_RS10505	2059045..2059341	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
ELZ49_RS10510	2059399..2059686	-	288	WP_001040261.1	hypothetical protein	-
ELZ49_RS10515	2059733..2059885	-	153	WP_001153681.1	hypothetical protein	-
ELZ49_RS10520	2059875..2063660	-	3786	WP_000582168.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL / hld	2054240..2133417	79177

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T286709 WP_011447039.1 NZ_LR134086:c2058895-2058719 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT286709 NZ_LR134086:2058588-2058727 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin