Detailed information of TA system TA286705

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1574728..1575307
• Replicon: chromosome
• Accession: NZ_LR134086
• Organism: Staphylococcus aureus strain NCTC13142

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: ELZ49_RS07775
• Protein ID: WP_001025401.1
• Coordinates: 1575062..1575307 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1574728..1575093 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELZ49_RS07735	1571475..1572029	-	555	WP_000647288.1	DUF2815 family protein	-
ELZ49_RS07740	1572055..1573221	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
ELZ49_RS07745	1573218..1573580	-	363	WP_000985986.1	hypothetical protein	-
ELZ49_RS07750	1573595..1573917	-	323	Protein_1461	TrmB family transcriptional regulator	-
ELZ49_RS07755	1573996..1574157	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
ELZ49_RS07760	1574170..1574433	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
ELZ49_RS07765	1574458..1574673	-	216	WP_001097552.1	hypothetical protein	-
ELZ49_RS07770	1574728..1575093	+	366	WP_001128433.1	hypothetical protein	Antitoxin
ELZ49_RS07775	1575062..1575307	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
ELZ49_RS07780	1575374..1575754	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
ELZ49_RS07785	1575741..1575938	-	198	WP_001148860.1	hypothetical protein	-
ELZ49_RS07790	1576008..1576220	+	213	WP_000362644.1	hypothetical protein	-
ELZ49_RS14695	1576261..1576410	-	150	WP_000771849.1	hypothetical protein	-
ELZ49_RS07795	1576425..1576868	-	444	WP_000435357.1	hypothetical protein	-
ELZ49_RS07800	1576916..1577128	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
ELZ49_RS07805	1577280..1578011	+	732	WP_000511090.1	XRE family transcriptional regulator	-
ELZ49_RS07810	1578082..1578264	+	183	WP_000705240.1	hypothetical protein	-
ELZ49_RS07815	1578302..1578448	+	147	WP_001795334.1	hypothetical protein	-
ELZ49_RS07820	1578445..1579059	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1533601..1599764	66163

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T286705 WP_001025401.1 NZ_LR134086:c1575307-1575062 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT286705 NZ_LR134086:1574728-1575093 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin