Detailed information of TA system TA286702

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 1538359..1538666
• Replicon: chromosome
• Accession: NZ_LR134086
• Organism: Staphylococcus aureus strain NCTC13142

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ELZ49_RS07525
• Protein ID: WP_011447039.1
• Coordinates: 1538490..1538666 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1538359..1538498 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELZ49_RS14780	1533601..1533816	-	216	WP_170267452.1	hypothetical protein	-
ELZ49_RS07500	1533995..1535005	-	1011	WP_000777019.1	restriction endonuclease subunit S	-
ELZ49_RS07505	1534992..1536896	-	1905	WP_001003363.1	N-6 DNA methylase	-
ELZ49_RS07510	1537257..1538012	-	756	WP_000861038.1	CHAP domain-containing protein	-
ELZ49_RS07515	1538024..1538278	-	255	WP_000611512.1	phage holin	-
ELZ49_RS07520	1538330..1538437	+	108	WP_001791821.1	hypothetical protein	-
-	1538359..1538498	+	140	NuclAT_0	-	Antitoxin
-	1538359..1538498	+	140	NuclAT_0	-	Antitoxin
-	1538359..1538498	+	140	NuclAT_0	-	Antitoxin
-	1538359..1538498	+	140	NuclAT_0	-	Antitoxin
ELZ49_RS07525	1538490..1538666	-	177	WP_011447039.1	putative holin-like toxin	Toxin
ELZ49_RS07530	1538819..1539118	-	300	WP_000466784.1	DUF2951 domain-containing protein	-
ELZ49_RS07535	1539164..1539328	-	165	WP_000916020.1	XkdX family protein	-
ELZ49_RS07540	1539321..1539710	-	390	WP_001166596.1	DUF2977 domain-containing protein	-
ELZ49_RS07545	1539710..1541175	-	1466	Protein_1420	phage baseplate upper protein	-
ELZ49_RS07550	1541175..1543084	-	1910	Protein_1421	hypothetical protein	-
ELZ49_RS07555	1543100..1543390	-	291	WP_000179858.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1533601..1599764	66163

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T286702 WP_011447039.1 NZ_LR134086:c1538666-1538490 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT286702 NZ_LR134086:1538359-1538498 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin