Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2560656..2561179 Replicon chromosome
Accession NZ_LR134085
Organism Staphylococcus aureus strain NCTC12233

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag ELZ52_RS13490 Protein ID WP_000074048.1
Coordinates 2560656..2560922 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag ELZ52_RS13495 Protein ID WP_000587616.1
Coordinates 2560922..2561179 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ52_RS13470 2555963..2557150 - 1188 WP_000026194.1 MFS transporter -
ELZ52_RS13475 2557546..2558322 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
ELZ52_RS13480 2558315..2558977 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
ELZ52_RS13485 2559225..2560301 - 1077 WP_001076686.1 M42 family metallopeptidase -
ELZ52_RS13490 2560656..2560922 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
ELZ52_RS13495 2560922..2561179 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ52_RS13500 2561285..2561479 - 195 WP_001790145.1 hypothetical protein -
ELZ52_RS13505 2561538..2561993 + 456 WP_000732082.1 DUF1307 domain-containing protein -
ELZ52_RS13510 2562161..2563738 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
ELZ52_RS13515 2563933..2564682 + 750 WP_000072443.1 hypothetical protein -
ELZ52_RS13520 2564906..2566099 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286700 WP_000074048.1 NZ_LR134085:c2560922-2560656 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286700 WP_000587616.1 NZ_LR134085:c2561179-2560922 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References