Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2503803..2504320 Replicon chromosome
Accession NZ_LR134085
Organism Staphylococcus aureus strain NCTC12233

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag ELZ52_RS13175 Protein ID WP_000113262.1
Coordinates 2503803..2504069 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ELZ52_RS13180 Protein ID WP_000584499.1
Coordinates 2504069..2504320 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ52_RS13145 2499229..2499765 - 537 WP_015581908.1 GNAT family N-acetyltransferase -
ELZ52_RS13150 2499998..2500822 - 825 WP_000572040.1 formate/nitrite transporter family protein -
ELZ52_RS13155 2501039..2501221 - 183 WP_000230294.1 hypothetical protein -
ELZ52_RS13160 2501305..2501772 - 468 WP_000153344.1 SRPBCC domain-containing protein -
ELZ52_RS13165 2501958..2503508 - 1551 WP_048520761.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ELZ52_RS13170 2503697..2503768 - 72 Protein_2429 hypothetical protein -
ELZ52_RS13175 2503803..2504069 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
ELZ52_RS13180 2504069..2504320 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ52_RS13185 2504485..2504586 - 102 WP_001791744.1 hypothetical protein -
ELZ52_RS13190 2504593..2505192 - 600 WP_061642043.1 DsbA family protein -
ELZ52_RS13195 2505211..2505573 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ELZ52_RS13200 2505828..2507078 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
ELZ52_RS13205 2507175..2507906 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
ELZ52_RS13210 2507903..2508622 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286698 WP_000113262.1 NZ_LR134085:c2504069-2503803 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286698 WP_000584499.1 NZ_LR134085:c2504320-2504069 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References