Detailed information of TA system TA286686

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 342685..343264
• Replicon: chromosome
• Accession: NZ_LR134085
• Organism: Staphylococcus aureus strain NCTC12233

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: ELZ52_RS01610
• Protein ID: WP_001025401.1
• Coordinates: 342685..342930 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	342899..343264 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELZ52_RS01565	338640..339263	+	624	WP_001166482.1	hypothetical protein	-
ELZ52_RS01570	339462..339857	-	396	WP_000449656.1	hypothetical protein	-
ELZ52_RS01575	339886..340320	-	435	WP_000755721.1	hypothetical protein	-
ELZ52_RS01580	340338..340799	-	462	WP_000524999.1	hypothetical protein	-
ELZ52_RS01585	340812..341141	-	330	WP_000429766.1	helix-turn-helix domain-containing protein	-
ELZ52_RS01590	341302..341493	+	192	WP_001115060.1	helix-turn-helix domain-containing protein	-
ELZ52_RS14940	341582..341731	+	150	WP_000771849.1	hypothetical protein	-
ELZ52_RS01595	341772..341984	-	213	WP_000362644.1	hypothetical protein	-
ELZ52_RS01600	342054..342251	+	198	WP_001148860.1	hypothetical protein	-
ELZ52_RS01605	342238..342618	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
ELZ52_RS01610	342685..342930	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
ELZ52_RS01615	342899..343264	-	366	WP_001128433.1	hypothetical protein	Antitoxin
ELZ52_RS01620	343319..343534	+	216	WP_001097552.1	hypothetical protein	-
ELZ52_RS01625	343561..343824	+	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
ELZ52_RS01630	343837..343998	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
ELZ52_RS01635	344077..344400	+	324	WP_000174998.1	hypothetical protein	-
ELZ52_RS01640	344415..344777	+	363	WP_000985976.1	hypothetical protein	-
ELZ52_RS01645	344774..345940	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-
ELZ52_RS01650	345966..346523	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	337325..381961	44636

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T286686 WP_001025401.1 NZ_LR134085:342685-342930 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT286686 NZ_LR134085:c343264-342899 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin