Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1787596..1788098 Replicon chromosome
Accession NZ_LR134082
Organism Escherichia coli strain NCTC9038

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL018_RS08570 Protein ID WP_000767829.1
Coordinates 1787844..1788098 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL018_RS08565 Protein ID WP_001259255.1
Coordinates 1787596..1787847 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL018_RS08540 1782774..1783841 - 1068 WP_000080118.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL018_RS08545 1783841..1784911 - 1071 WP_000108954.1 histidinol-phosphate transaminase -
EL018_RS08550 1784908..1786212 - 1305 WP_001300981.1 histidinol dehydrogenase -
EL018_RS08555 1786218..1787117 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL018_RS08560 1787263..1787313 - 51 WP_001364200.1 his operon leader peptide -
EL018_RS08565 1787596..1787847 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL018_RS08570 1787844..1788098 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL018_RS08575 1788181..1789005 + 825 WP_000754737.1 SDR family oxidoreductase -
EL018_RS08580 1789051..1789980 + 930 WP_001374016.1 LysR family transcriptional regulator -
EL018_RS08585 1790194..1790256 + 63 WP_010723108.1 membrane protein YoeI -
EL018_RS08590 1790246..1791604 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T286674 WP_000767829.1 NZ_LR134082:1787844-1788098 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT286674 WP_001259255.1 NZ_LR134082:1787596-1787847 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References