Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3872398..3872939 Replicon chromosome
Accession NZ_LR134080
Organism Escherichia coli strain NCTC9082

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag EL023_RS19085 Protein ID WP_000615976.1
Coordinates 3872661..3872939 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag EL023_RS19080 Protein ID WP_000729704.1
Coordinates 3872398..3872658 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL023_RS19055 3868181..3868966 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
EL023_RS19060 3868938..3870650 + 1713 Protein_3664 flagellar biosynthesis protein FlhA -
EL023_RS19065 3870755..3871033 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
EL023_RS19070 3871026..3871382 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
EL023_RS19075 3871439..3872212 - 774 WP_000543897.1 C40 family peptidase -
EL023_RS19080 3872398..3872658 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EL023_RS19085 3872661..3872939 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EL023_RS19090 3873095..3873835 + 741 WP_001225679.1 murein L,D-transpeptidase -
EL023_RS19095 3873806..3874573 - 768 WP_000333380.1 class II glutamine amidotransferase -
EL023_RS19100 3874779..3875357 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T286664 WP_000615976.1 NZ_LR134080:3872661-3872939 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT286664 WP_000729704.1 NZ_LR134080:3872398-3872658 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References