Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1887902..1888404 Replicon chromosome
Accession NZ_LR134080
Organism Escherichia coli strain NCTC9082

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL023_RS09105 Protein ID WP_000767829.1
Coordinates 1888150..1888404 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL023_RS09100 Protein ID WP_001259255.1
Coordinates 1887902..1888153 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL023_RS09075 1883080..1884147 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL023_RS09080 1884147..1885217 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
EL023_RS09085 1885214..1886518 - 1305 WP_000009594.1 histidinol dehydrogenase -
EL023_RS09090 1886524..1887423 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL023_RS09095 1887569..1887619 - 51 WP_001364200.1 his operon leader peptide -
EL023_RS09100 1887902..1888153 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL023_RS09105 1888150..1888404 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL023_RS09110 1888487..1889311 + 825 WP_000754737.1 SDR family oxidoreductase -
EL023_RS09115 1889357..1890286 + 930 WP_000803351.1 LysR family transcriptional regulator -
EL023_RS09120 1890501..1890563 + 63 WP_010723108.1 membrane protein YoeI -
EL023_RS09125 1890553..1891911 + 1359 WP_053880142.1 putrescine/proton symporter PlaP -
EL023_RS09130 1892090..1893148 + 1059 WP_000492339.1 transport protein YeeE -
EL023_RS09135 1893162..1893389 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T286653 WP_000767829.1 NZ_LR134080:1888150-1888404 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT286653 WP_001259255.1 NZ_LR134080:1887902-1888153 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References