Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1764288..1764790 Replicon chromosome
Accession NZ_LR134075
Organism Escherichia coli strain NCTC9084

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL019_RS08415 Protein ID WP_000767829.1
Coordinates 1764536..1764790 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL019_RS08410 Protein ID WP_001259255.1
Coordinates 1764288..1764539 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL019_RS08385 1759466..1760533 - 1068 WP_000080089.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL019_RS08390 1760533..1761603 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
EL019_RS08395 1761600..1762904 - 1305 WP_001317939.1 histidinol dehydrogenase -
EL019_RS08400 1762910..1763809 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL019_RS08405 1763955..1764005 - 51 WP_001364200.1 his operon leader peptide -
EL019_RS08410 1764288..1764539 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL019_RS08415 1764536..1764790 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL019_RS08420 1764873..1765697 + 825 WP_000754763.1 SDR family oxidoreductase -
EL019_RS08425 1765743..1766672 + 930 WP_000803351.1 LysR family transcriptional regulator -
EL019_RS08430 1766887..1766949 + 63 WP_010723108.1 membrane protein YoeI -
EL019_RS08435 1766939..1768297 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL019_RS08440 1768476..1769534 + 1059 WP_000492315.1 transport protein YeeE -
EL019_RS08445 1769548..1769775 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T286609 WP_000767829.1 NZ_LR134075:1764536-1764790 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT286609 WP_001259255.1 NZ_LR134075:1764288-1764539 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References