Detailed information of TA system TA286597

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 4178694..4179106
• Replicon: chromosome
• Accession: NZ_LR134031
• Organism: Escherichia coli strain NCTC11151

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8E0IWC4
• Locus tag: EL024_RS20835
• Protein ID: WP_001513534.1
• Coordinates: 4178765..4179106 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4178694..4178770 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL024_RS20825	4175306..4176775	+	1470	WP_001387312.1	type I restriction-modification system subunit M	-
EL024_RS20830	4176775..4178544	+	1770	WP_001513535.1	restriction endonuclease subunit S	-
-	4178694..4178770	-	77	NuclAT_6	-	Antitoxin
-	4178694..4178770	-	77	NuclAT_6	-	Antitoxin
-	4178694..4178770	-	77	NuclAT_6	-	Antitoxin
-	4178694..4178770	-	77	NuclAT_6	-	Antitoxin
-	4178694..4178770	-	77	NuclAT_7	-	Antitoxin
-	4178694..4178770	-	77	NuclAT_7	-	Antitoxin
-	4178694..4178770	-	77	NuclAT_7	-	Antitoxin
-	4178694..4178770	-	77	NuclAT_7	-	Antitoxin
EL024_RS20835	4178765..4179106	+	342	WP_001513534.1	endoribonuclease SymE	Toxin
EL024_RS20840	4179153..4181309	-	2157	WP_001513533.1	DUF262 domain-containing protein	-
EL024_RS20845	4181344..4181424	-	81	WP_020233658.1	hypothetical protein	-
EL024_RS20850	4181652..4182572	-	921	WP_001513532.1	Rpn family recombination-promoting nuclease/putative transposase	-
EL024_RS20855	4182757..4184037	+	1281	WP_001338077.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	cheD	4163082..4179106	16024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12247.03 Da
• Isoelectric Point: 7.8545

>T286597 WP_001513534.1 NZ_LR134031:4178765-4179106 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASHYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

Antitoxin

Nucleotide

• Length: 77 bp

>AT286597 NZ_LR134031:c4178770-4178694 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin