Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4052643..4052901 Replicon chromosome
Accession NZ_LR134031
Organism Escherichia coli strain NCTC11151

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag EL024_RS20110 Protein ID WP_000809168.1
Coordinates 4052749..4052901 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4052643..4052700 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL024_RS20095 4048475..4049734 - 1260 WP_000494924.1 hypothetical protein -
EL024_RS20100 4049863..4051356 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
EL024_RS20105 4051376..4052137 - 762 WP_001274823.1 hypothetical protein -
- 4052643..4052700 - 58 - - Antitoxin
EL024_RS20110 4052749..4052901 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
EL024_RS20115 4053006..4054136 - 1131 WP_001118464.1 molecular chaperone DnaJ -
EL024_RS20120 4054225..4056141 - 1917 WP_000516135.1 molecular chaperone DnaK -
EL024_RS20125 4056513..4056917 + 405 WP_000843687.1 DUF2541 family protein -
EL024_RS20130 4056943..4057656 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T286596 WP_000809168.1 NZ_LR134031:4052749-4052901 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT286596 NZ_LR134031:c4052700-4052643 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References