Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2559088..2559650 Replicon chromosome
Accession NZ_LR134031
Organism Escherichia coli strain NCTC11151

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag EL024_RS12790 Protein ID WP_000605675.1
Coordinates 2559088..2559366 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag EL024_RS12795 Protein ID WP_000781370.1
Coordinates 2559366..2559650 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL024_RS12765 2554674..2555105 - 432 WP_000152310.1 peroxiredoxin OsmC -
EL024_RS12770 2555450..2555665 + 216 WP_000495766.1 biofilm-dependent modulation protein -
EL024_RS12775 2555767..2555904 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
EL024_RS12780 2556055..2557758 + 1704 WP_126489901.1 malate dehydrogenase -
EL024_RS12785 2557892..2558902 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
EL024_RS12790 2559088..2559366 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL024_RS12795 2559366..2559650 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
EL024_RS12800 2559879..2560532 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
EL024_RS12805 2560525..2561409 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
EL024_RS12810 2561422..2564469 - 3048 WP_115205716.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T286591 WP_000605675.1 NZ_LR134031:2559088-2559366 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT286591 WP_000781370.1 NZ_LR134031:2559366-2559650 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References