Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1986364..1986866 Replicon chromosome
Accession NZ_LR134031
Organism Escherichia coli strain NCTC11151

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL024_RS09745 Protein ID WP_000767829.1
Coordinates 1986612..1986866 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL024_RS09740 Protein ID WP_001259255.1
Coordinates 1986364..1986615 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL024_RS09715 1981542..1982609 - 1068 WP_001513846.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL024_RS09720 1982609..1983679 - 1071 WP_000108943.1 histidinol-phosphate transaminase -
EL024_RS09725 1983676..1984980 - 1305 WP_001513845.1 histidinol dehydrogenase -
EL024_RS09730 1984986..1985885 - 900 WP_000131789.1 ATP phosphoribosyltransferase -
EL024_RS09735 1986031..1986081 - 51 WP_071593552.1 his operon leader peptide -
EL024_RS09740 1986364..1986615 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL024_RS09745 1986612..1986866 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL024_RS09750 1986949..1987773 + 825 WP_000754737.1 SDR family oxidoreductase -
EL024_RS09755 1987819..1988748 + 930 WP_000803351.1 LysR family transcriptional regulator -
EL024_RS09760 1988963..1989025 + 63 WP_010723108.1 membrane protein YoeI -
EL024_RS09765 1989015..1990373 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL024_RS09770 1990552..1991610 + 1059 WP_000492340.1 transport protein YeeE -
EL024_RS09775 1991624..1991851 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T286585 WP_000767829.1 NZ_LR134031:1986612-1986866 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT286585 WP_001259255.1 NZ_LR134031:1986364-1986615 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References