Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 612035..612834 Replicon chromosome
Accession NZ_LR134000
Organism Escherichia coli strain NCTC9066

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag EL014_RS02970 Protein ID WP_000347251.1
Coordinates 612035..612499 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag EL014_RS02975 Protein ID WP_012304834.1
Coordinates 612499..612834 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL014_RS02940 607036..607470 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
EL014_RS02945 607488..608366 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EL014_RS02950 608356..609135 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EL014_RS02955 609146..609619 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EL014_RS02960 609642..610922 - 1281 WP_000681905.1 tagatose-bisphosphate aldolase subunit KbaZ -
EL014_RS02965 611171..611980 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
EL014_RS02970 612035..612499 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EL014_RS02975 612499..612834 - 336 WP_012304834.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EL014_RS02980 612983..614554 - 1572 WP_001273760.1 galactarate dehydratase -
EL014_RS02985 614929..616263 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
EL014_RS02990 616279..617049 + 771 WP_001058236.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T286559 WP_000347251.1 NZ_LR134000:c612499-612035 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12344.95 Da        Isoelectric Point: 4.6890

>AT286559 WP_012304834.1 NZ_LR134000:c612834-612499 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure

References