Detailed information of TA system TA286543

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 673496..673757
• Replicon: chromosome
• Accession: NZ_LR133996
• Organism: Shimwellia blattae strain NCTC10965

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: EL017_RS03200
• Protein ID: WP_014715816.1
• Coordinates: 673596..673757 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	673496..673532 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL017_RS03175	669191..669481	+	291	WP_002444900.1	citrate lyase acyl carrier protein	-
EL017_RS03180	669478..670353	+	876	WP_002444902.1	citrate (pro-3S)-lyase subunit beta	-
EL017_RS03185	670364..671881	+	1518	WP_002444904.1	citrate lyase subunit alpha	-
EL017_RS03190	671886..672425	+	540	WP_002444905.1	citrate lyase holo-[acyl-carrier protein] synthase	-
EL017_RS03195	672403..673261	+	859	Protein_619	triphosphoribosyl-dephospho-CoA synthase CitG	-
-	673496..673532	-	37	-	-	Antitoxin
EL017_RS03200	673596..673757	+	162	WP_014715816.1	Hok/Gef family protein	Toxin
EL017_RS03205	674164..674325	+	162	WP_071840846.1	Hok/Gef family protein	-
EL017_RS03210	674443..675528	-	1086	WP_002444912.1	membrane-bound lytic murein transglycosylase MltC	-
EL017_RS03215	675628..675900	-	273	WP_002444915.1	oxidative damage protection protein	-
EL017_RS03220	675903..676985	-	1083	WP_002444917.1	A/G-specific adenine glycosylase	-
EL017_RS03225	677142..677861	+	720	WP_002444919.1	tRNA (guanosine(46)-N7)-methyltransferase TrmB	-
EL017_RS03230	677861..678187	+	327	WP_002444921.1	YggL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	649575..675555	25980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 5822.12 Da
• Isoelectric Point: 7.5949

>T286543 WP_014715816.1 NZ_LR133996:673596-673757 [Shimwellia blattae]
MKLSQYSAVWCLLIVCLTLLLLTLIIRPQLCEVRIIQGDREIAAIMACGSGTS

Nucleotide

• Length: 162 bp

Antitoxin

Nucleotide

• Length: 37 bp

>AT286543 NZ_LR133996:c673532-673496 [Shimwellia blattae]
GGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Structures

Antitoxin