Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 80177..80898 Replicon chromosome
Accession NZ_LR133996
Organism Shimwellia blattae strain NCTC10965

Toxin (Protein)


Gene name higB Uniprot ID I2B3V7
Locus tag EL017_RS00345 Protein ID WP_002440752.1
Coordinates 80177..80488 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL017_RS00350 Protein ID WP_002440751.1
Coordinates 80485..80898 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL017_RS00320 77005..77835 + 831 WP_002440759.1 formate dehydrogenase accessory sulfurtransferase FdhD -
EL017_RS00325 78128..78340 + 213 WP_002440757.1 DUF1471 domain-containing protein -
EL017_RS00330 78382..78705 - 324 WP_002440756.1 AzlD domain-containing protein -
EL017_RS00335 78705..79367 - 663 WP_002440754.1 AzlC family ABC transporter permease -
EL017_RS00340 79506..80054 + 549 WP_002440753.1 XRE family transcriptional regulator -
EL017_RS00345 80177..80488 + 312 WP_002440752.1 type II toxin-antitoxin system HigB family toxin Toxin
EL017_RS00350 80485..80898 + 414 WP_002440751.1 helix-turn-helix domain-containing protein Antitoxin
EL017_RS00355 80957..81271 - 315 WP_034920130.1 L-rhamnose mutarotase -
EL017_RS00360 81283..82431 - 1149 WP_002440748.1 lactaldehyde reductase -
EL017_RS00365 82457..83281 - 825 WP_002440747.1 rhamnulose-1-phosphate aldolase -
EL017_RS00370 83341..84600 - 1260 WP_002440746.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.31 Da        Isoelectric Point: 9.9315

>T286542 WP_002440752.1 NZ_LR133996:80177-80488 [Shimwellia blattae]
MHIISRAPFDTATKIFPNQAAALDDLYRVLKRENYRSPDEMRMQFPSLDRMKLREKWWVIDVGGGQLRVMFFADFERGKL
FIKHISTHAEYDKLTDYYRRNKE

Download         Length: 312 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15337.62 Da        Isoelectric Point: 5.2376

>AT286542 WP_002440751.1 NZ_LR133996:80485-80898 [Shimwellia blattae]
VSYAEAIKTAQALATMFPLLGGSTSRKDYEDALRMVEYLVEHEPDSPLIDMLAARIEKYEDEAPEFAEFNARIASVPAGV
SVLRVIMDQYHLTQSDFEQEIGKKSLVSRILSGQRSLTLAHIKALAARFHIKPELFL

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2B3V7

Antitoxin

Source ID Structure

References