286526

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2645532..2646775 Replicon chromosome
Accession NZ_LR133933
Organism Legionella pneumophila strain NCTC12180

Toxin (Protein)


Gene name HipT Uniprot ID Q5ZSZ6
Locus tag ELZ66_RS11995 Protein ID WP_010948074.1
Coordinates 2645837..2646775 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag ELZ66_RS11990 Protein ID WP_010948073.1
Coordinates 2645532..2645840 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ66_RS11965 2640968..2641333 + 366 WP_010948069.1 BRCT domain-containing protein -
ELZ66_RS11970 2641690..2642055 - 366 WP_010948070.1 TraK family protein -
ELZ66_RS15375 2642240..2642380 - 141 WP_153802426.1 hypothetical protein -
ELZ66_RS11975 2642383..2644134 - 1752 WP_010948071.1 DUF927 domain-containing protein -
ELZ66_RS11980 2644200..2644475 - 276 WP_010948072.1 helix-turn-helix domain-containing protein -
ELZ66_RS11985 2645308..2645535 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
ELZ66_RS11990 2645532..2645840 + 309 WP_010948073.1 HipA N-terminal domain-containing protein Antitoxin
ELZ66_RS11995 2645837..2646775 + 939 WP_010948074.1 lpg2370 family Dot/Icm T4SS effector Toxin
ELZ66_RS12005 2647318..2647932 + 615 WP_010948075.1 hypothetical protein -
ELZ66_RS12010 2648088..2648294 - 207 WP_015444115.1 hypothetical protein -
ELZ66_RS12015 2648631..2649899 + 1269 WP_010948076.1 lpg2372 family Dot/Icm T4SS effector -
ELZ66_RS12020 2650115..2650640 - 526 Protein_2311 hypothetical protein -
ELZ66_RS12025 2650640..2651305 - 666 WP_015444114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36077.81 Da        Isoelectric Point: 8.6882

>T286526 WP_010948074.1 NZ_LR133933:2645837-2646775 [Legionella pneumophila]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT286526 WP_010948073.1 NZ_LR133933:2645532-2645840 [Legionella pneumophila]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VKC
PDB 7VKB
PDB 7WCF

Antitoxin

Source ID Structure
AlphaFold DB Q5ZSZ7

References