Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2470056..2470579 Replicon chromosome
Accession NZ_LR133917
Organism Staphylococcus aureus strain NCTC8317

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag ELZ45_RS12840 Protein ID WP_000074045.1
Coordinates 2470056..2470322 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag ELZ45_RS12845 Protein ID WP_000587619.1
Coordinates 2470322..2470579 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ45_RS12820 2465362..2466549 - 1188 WP_000026189.1 MFS transporter -
ELZ45_RS12825 2466945..2467721 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
ELZ45_RS12830 2467714..2468376 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
ELZ45_RS12835 2468624..2469700 - 1077 WP_001076673.1 M42 family metallopeptidase -
ELZ45_RS12840 2470056..2470322 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
ELZ45_RS12845 2470322..2470579 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ45_RS12855 2470939..2471394 + 456 WP_000732082.1 DUF1307 domain-containing protein -
ELZ45_RS12860 2471562..2473139 - 1578 WP_000143502.1 FMN-binding glutamate synthase family protein -
ELZ45_RS12865 2473334..2474083 + 750 WP_000072440.1 hypothetical protein -
ELZ45_RS12870 2474314..2475507 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T286518 WP_000074045.1 NZ_LR133917:c2470322-2470056 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT286518 WP_000587619.1 NZ_LR133917:c2470579-2470322 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References