Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4280789..4281047 Replicon chromosome
Accession NZ_LR130564
Organism Escherichia coli strain MS14387 isolate MS14387

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FVE81_RS20920 Protein ID WP_000809168.1
Coordinates 4280895..4281047 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4280789..4280846 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE81_RS20905 4277181..4278140 + 960 WP_000871674.1 hypothetical protein -
FVE81_RS20910 4278178..4279077 - 900 WP_001300855.1 transcriptional activator NhaR -
FVE81_RS20915 4279143..4280309 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4280789..4280846 - 58 - - Antitoxin
FVE81_RS20920 4280895..4281047 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
FVE81_RS20925 4281151..4282281 - 1131 WP_001118464.1 molecular chaperone DnaJ -
FVE81_RS20930 4282370..4284286 - 1917 WP_000516135.1 molecular chaperone DnaK -
FVE81_RS20935 4284662..4285066 + 405 WP_000843584.1 DUF2541 family protein -
FVE81_RS20940 4285092..4285805 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T286492 WP_000809168.1 NZ_LR130564:4280895-4281047 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT286492 NZ_LR130564:c4280846-4280789 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References