286478

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 749870..750563 Replicon chromosome
Accession NZ_LR130564
Organism Escherichia coli strain MS14387 isolate MS14387

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag FVE81_RS03635 Protein ID WP_000415585.1
Coordinates 749870..750166 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FVE81_RS03640 Protein ID WP_000650107.1
Coordinates 750168..750563 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE81_RS03605 745004..746196 + 1193 Protein_706 Hcp family type VI secretion system effector -
FVE81_RS03610 746203..746535 + 333 WP_000914691.1 DUF2645 family protein -
FVE81_RS03615 746581..747930 - 1350 WP_000673357.1 two-component system sensor histidine kinase QseC -
FVE81_RS03620 747927..748586 - 660 WP_001221493.1 two-component system response regulator QseB -
FVE81_RS03625 748738..749130 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FVE81_RS03630 749183..749665 + 483 WP_000183505.1 transcriptional regulator -
FVE81_RS03635 749870..750166 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
FVE81_RS03640 750168..750563 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FVE81_RS03645 750696..752303 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FVE81_RS03650 752441..754699 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T286478 WP_000415585.1 NZ_LR130564:749870-750166 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT286478 WP_000650107.1 NZ_LR130564:750168-750563 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References