Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1923614..1924116 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0H2Z0A6
Locus tag EW037_RS09255 Protein ID WP_000767826.1
Coordinates 1923862..1924116 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EW037_RS09250 Protein ID WP_001259255.1
Coordinates 1923614..1923865 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS09225 1918792..1919859 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EW037_RS09230 1919859..1920929 - 1071 WP_064770503.1 histidinol-phosphate transaminase -
EW037_RS09235 1920926..1922230 - 1305 WP_001350692.1 histidinol dehydrogenase -
EW037_RS09240 1922236..1923135 - 900 WP_064770504.1 ATP phosphoribosyltransferase -
EW037_RS09245 1923281..1923331 - 51 WP_001364200.1 his operon leader peptide -
EW037_RS09250 1923614..1923865 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EW037_RS09255 1923862..1924116 + 255 WP_000767826.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EW037_RS09260 1924199..1925023 + 825 WP_000754737.1 SDR family oxidoreductase -
EW037_RS09265 1925069..1925998 + 930 WP_000803366.1 LysR family transcriptional regulator -
EW037_RS09270 1926213..1926275 + 63 WP_010723108.1 membrane protein YoeI -
EW037_RS09275 1926265..1927623 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EW037_RS09280 1927802..1928860 + 1059 WP_064770505.1 transport protein YeeE -
EW037_RS09285 1928874..1929101 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T286456 WP_000767826.1 NZ_LR130562:1923862-1924116 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRIIEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT286456 WP_001259255.1 NZ_LR130562:1923614-1923865 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z0A6

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References