Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 651156..651955 Replicon chromosome
Accession NZ_LR130555
Organism Escherichia coli strain MS14385 isolate MS14385

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag EW040_RS03165 Protein ID WP_000347273.1
Coordinates 651156..651620 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag EW040_RS03170 Protein ID WP_001308975.1
Coordinates 651620..651955 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW040_RS03135 646157..646591 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
EW040_RS03140 646609..647487 - 879 WP_001298314.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EW040_RS03145 647477..648256 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EW040_RS03150 648267..648740 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EW040_RS03155 648763..650043 - 1281 WP_023908831.1 tagatose-bisphosphate aldolase subunit KbaZ -
EW040_RS03160 650292..651101 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
EW040_RS03165 651156..651620 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EW040_RS03170 651620..651955 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EW040_RS03175 652104..653675 - 1572 WP_023908830.1 galactarate dehydratase -
EW040_RS03180 654050..655384 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
EW040_RS03185 655400..656170 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T286419 WP_000347273.1 NZ_LR130555:c651620-651156 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT286419 WP_001308975.1 NZ_LR130555:c651955-651620 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References