Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1868029..1868531 Replicon chromosome
Accession NZ_LR130552
Organism Escherichia coli strain MS14386 isolate MS14386

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EW035_RS08840 Protein ID WP_000767829.1
Coordinates 1868277..1868531 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EW035_RS08835 Protein ID WP_001259255.1
Coordinates 1868029..1868280 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW035_RS08810 1863206..1864273 - 1068 WP_000080060.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EW035_RS08815 1864273..1865343 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
EW035_RS08820 1865340..1866644 - 1305 WP_001317939.1 histidinol dehydrogenase -
EW035_RS08825 1866650..1867549 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EW035_RS08830 1867695..1867745 - 51 WP_001364200.1 his operon leader peptide -
EW035_RS08835 1868029..1868280 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EW035_RS08840 1868277..1868531 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EW035_RS08845 1868614..1869438 + 825 WP_000754758.1 SDR family oxidoreductase -
EW035_RS08850 1869484..1870413 + 930 WP_000803351.1 LysR family transcriptional regulator -
EW035_RS08855 1870628..1870690 + 63 WP_010723108.1 membrane protein YoeI -
EW035_RS08860 1870680..1872038 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EW035_RS08865 1872217..1873275 + 1059 WP_000492346.1 transport protein YeeE -
EW035_RS08870 1873289..1873516 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T286399 WP_000767829.1 NZ_LR130552:1868277-1868531 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT286399 WP_001259255.1 NZ_LR130552:1868029-1868280 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References