Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4937282..4937884 Replicon chromosome
Accession NZ_LR130545
Organism Escherichia coli strain B36 isolate B36

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag EW036_RS24715 Protein ID WP_000897302.1
Coordinates 4937573..4937884 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EW036_RS24710 Protein ID WP_000356397.1
Coordinates 4937282..4937572 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW036_RS24670 4932589..4933518 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
EW036_RS24675 4933700..4933942 - 243 WP_001068514.1 ribbon-helix-helix domain-containing protein -
EW036_RS24680 4934232..4935080 + 849 WP_001038650.1 hypothetical protein -
EW036_RS24685 4935396..4935845 + 450 WP_032140890.1 hypothetical protein -
EW036_RS24690 4936030..4936248 - 219 WP_001251293.1 ribbon-helix-helix domain-containing protein -
EW036_RS24700 4936645..4936923 - 279 WP_001296612.1 hypothetical protein -
EW036_RS24710 4937282..4937572 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
EW036_RS24715 4937573..4937884 - 312 WP_000897302.1 hypothetical protein Toxin
EW036_RS24720 4938113..4939021 + 909 WP_001385591.1 alpha/beta hydrolase -
EW036_RS24725 4939085..4940026 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
EW036_RS24730 4940071..4940508 - 438 WP_000560981.1 D-tyrosyl-tRNA(Tyr) deacylase -
EW036_RS24735 4940505..4941377 - 873 WP_000920762.1 virulence factor BrkB family protein -
EW036_RS24740 4941371..4941970 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T286373 WP_000897302.1 NZ_LR130545:c4937884-4937573 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT286373 WP_000356397.1 NZ_LR130545:c4937572-4937282 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References