286363

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2994211..2994713 Replicon chromosome
Accession NZ_LR130545
Organism Escherichia coli strain B36 isolate B36

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag EW036_RS15310 Protein ID WP_000767819.1
Coordinates 2994211..2994465 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag EW036_RS15315 Protein ID WP_001259253.1
Coordinates 2994462..2994713 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW036_RS15280 2990029..2990487 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
EW036_RS15290 2990704..2992062 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
EW036_RS15295 2992052..2992114 - 63 WP_010723108.1 membrane protein YoeI -
EW036_RS15300 2992329..2993258 - 930 WP_000803366.1 LysR family transcriptional regulator -
EW036_RS15305 2993304..2994128 - 825 WP_000754737.1 SDR family oxidoreductase -
EW036_RS15310 2994211..2994465 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EW036_RS15315 2994462..2994713 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EW036_RS15325 2994996..2995046 + 51 WP_001364200.1 his operon leader peptide -
EW036_RS15330 2995192..2996091 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
EW036_RS15335 2996097..2997401 + 1305 WP_001296211.1 histidinol dehydrogenase -
EW036_RS15340 2997398..2998468 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
EW036_RS15345 2998468..2999535 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2990029..2990487 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T286363 WP_000767819.1 NZ_LR130545:c2994465-2994211 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT286363 WP_001259253.1 NZ_LR130545:c2994713-2994462 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References