Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4001612..4002209 Replicon chromosome
Accession NZ_LR130544
Organism Klebsiella variicola strain 03-311-0071 isolate 03-311-0071

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EW041_RS19690 Protein ID WP_129766072.1
Coordinates 4001892..4002209 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EW041_RS19685 Protein ID WP_012542525.1
Coordinates 4001612..4001899 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW041_RS19655 3997473..3997721 + 249 WP_008805539.1 DUF1158 domain-containing protein -
EW041_RS19660 3997738..3998079 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
EW041_RS19665 3998110..3999225 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
EW041_RS19670 3999405..3999986 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
EW041_RS19675 3999986..4000354 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
EW041_RS19680 4000474..4001127 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
EW041_RS19685 4001612..4001899 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
EW041_RS19690 4001892..4002209 - 318 WP_129766072.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW041_RS19695 4002394..4003437 - 1044 WP_016160437.1 DUF2157 domain-containing protein -
EW041_RS19705 4004105..4004971 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
EW041_RS19710 4005080..4006507 + 1428 WP_129766073.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12140.48 Da        Isoelectric Point: 11.2767

>T286343 WP_129766072.1 NZ_LR130544:c4002209-4001892 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKMLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT286343 WP_012542525.1 NZ_LR130544:c4001899-4001612 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References