Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1839019..1839679 Replicon chromosome
Accession NZ_LR130544
Organism Klebsiella variicola strain 03-311-0071 isolate 03-311-0071

Toxin (Protein)


Gene name higB Uniprot ID A0A8B6IX92
Locus tag EW041_RS09045 Protein ID WP_008804168.1
Coordinates 1839326..1839679 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EW041_RS09040 Protein ID WP_032700907.1
Coordinates 1839019..1839321 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW041_RS09000 1834363..1835463 - 1101 WP_064160538.1 phosphotransferase -
EW041_RS09010 1835991..1836248 + 258 WP_012541132.1 antitoxin -
EW041_RS09015 1836249..1836581 + 333 WP_008804165.1 type II toxin-antitoxin system PemK/MazF family toxin -
EW041_RS09025 1836904..1838340 + 1437 WP_042948427.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
EW041_RS09035 1838666..1838815 - 150 Protein_1729 antitoxin -
EW041_RS09040 1839019..1839321 - 303 WP_032700907.1 XRE family transcriptional regulator Antitoxin
EW041_RS09045 1839326..1839679 - 354 WP_008804168.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW041_RS09050 1839883..1841364 + 1482 WP_008804169.1 hypothetical protein -
EW041_RS09055 1841453..1842907 - 1455 WP_008804170.1 AMP nucleosidase -
EW041_RS09060 1843038..1843283 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13528.51 Da        Isoelectric Point: 10.1729

>T286337 WP_008804168.1 NZ_LR130544:c1839679-1839326 [Klebsiella variicola]
VWTIKTTDMFDRWFTSLNDIDRASVLAALLVLREKGPGLSRPYADTIRGSRYSNMKELRVQSRGDPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYHEMLAVADREFTNWLNRLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11134.95 Da        Isoelectric Point: 5.7424

>AT286337 WP_032700907.1 NZ_LR130544:c1839321-1839019 [Klebsiella variicola]
MGRTLEQLLIDEKPDVVAEAQAIAKDILLNIHLAELREKVQKTQVEMAQNLGIKQPTVAGMEKPGRDLKLSTLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B6IX92

Antitoxin

Source ID Structure

References