Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 341658..342304 Replicon chromosome
Accession NZ_LR130543
Organism Klebsiella variicola strain 04153260899A isolate 04153260899A

Toxin (Protein)


Gene name higB Uniprot ID A0A2V3KK24
Locus tag EW039_RS01575 Protein ID WP_032731351.1
Coordinates 341658..342005 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag EW039_RS01580 Protein ID WP_008806992.1
Coordinates 342005..342304 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW039_RS01565 337545..338978 + 1434 WP_004202133.1 glycogen synthase GlgA -
EW039_RS01570 338996..341443 + 2448 WP_008806990.1 glycogen phosphorylase -
EW039_RS01575 341658..342005 + 348 WP_032731351.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW039_RS01580 342005..342304 + 300 WP_008806992.1 helix-turn-helix transcriptional regulator Antitoxin
EW039_RS01585 342367..343875 - 1509 WP_008806993.1 glycerol-3-phosphate dehydrogenase -
EW039_RS01590 344080..344409 + 330 WP_004202138.1 thiosulfate sulfurtransferase GlpE -
EW039_RS01595 344460..345290 + 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
EW039_RS01600 345340..346098 + 759 WP_008806995.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13474.43 Da        Isoelectric Point: 6.2327

>T286320 WP_032731351.1 NZ_LR130543:341658-342005 [Klebsiella variicola]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT286320 WP_008806992.1 NZ_LR130543:342005-342304 [Klebsiella variicola]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3KK24

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References