Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 362756..363402 Replicon chromosome
Accession NZ_LR130541
Organism Klebsiella pneumoniae strain AJ218 isolate AJ218

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EW045_RS01710 Protein ID WP_048269556.1
Coordinates 362756..363103 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag EW045_RS01715 Protein ID WP_004174017.1
Coordinates 363103..363402 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW045_RS01700 358682..360115 + 1434 WP_002920564.1 glycogen synthase GlgA -
EW045_RS01705 360133..362580 + 2448 WP_002920561.1 glycogen phosphorylase -
EW045_RS01710 362756..363103 + 348 WP_048269556.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW045_RS01715 363103..363402 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
EW045_RS01720 363465..364973 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
EW045_RS01725 365178..365507 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
EW045_RS01730 365558..366388 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
EW045_RS01735 366438..367196 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13558.57 Da        Isoelectric Point: 6.0884

>T286304 WP_048269556.1 NZ_LR130541:362756-363103 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELHSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT286304 WP_004174017.1 NZ_LR130541:363103-363402 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References