Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4052538..4053135 Replicon chromosome
Accession NZ_LR130539
Organism Klebsiella variicola strain AJ055 isolate AJ055

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag EW050_RS20030 Protein ID WP_012542526.1
Coordinates 4052818..4053135 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EW050_RS20025 Protein ID WP_012542525.1
Coordinates 4052538..4052825 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW050_RS19995 4048404..4048652 + 249 WP_008805539.1 DUF1158 domain-containing protein -
EW050_RS20000 4048669..4049010 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
EW050_RS20005 4049041..4050156 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
EW050_RS20010 4050336..4050917 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
EW050_RS20015 4050917..4051285 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
EW050_RS20020 4051405..4052058 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
EW050_RS20025 4052538..4052825 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
EW050_RS20030 4052818..4053135 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW050_RS20035 4053320..4054363 - 1044 WP_016160437.1 DUF2157 domain-containing protein -
EW050_RS20045 4054893..4055759 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
EW050_RS20050 4055868..4057295 + 1428 WP_040973773.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T286295 WP_012542526.1 NZ_LR130539:c4053135-4052818 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT286295 WP_012542525.1 NZ_LR130539:c4052825-4052538 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References