Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5391229..5391824 Replicon chromosome
Accession NZ_LR130537
Organism Pseudomonas aeruginosa isolate paerg012

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag EJN51_RS25565 Protein ID WP_003117425.1
Coordinates 5391546..5391824 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EJN51_RS25560 Protein ID WP_003113527.1
Coordinates 5391229..5391534 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN51_RS25525 5386313..5386600 - 288 WP_088130743.1 DUF5447 family protein -
EJN51_RS25530 5386776..5387048 - 273 WP_004352675.1 hypothetical protein -
EJN51_RS25540 5387495..5387830 + 336 WP_079262960.1 hypothetical protein -
EJN51_RS25545 5387842..5388513 - 672 WP_125075348.1 hypothetical protein -
EJN51_RS25550 5388515..5389642 - 1128 WP_125075349.1 hypothetical protein -
EJN51_RS25555 5389635..5390612 - 978 WP_125080763.1 hypothetical protein -
EJN51_RS25560 5391229..5391534 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
EJN51_RS25565 5391546..5391824 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJN51_RS25575 5392153..5394381 + 2229 WP_003113525.1 TonB-dependent receptor -
EJN51_RS25580 5394451..5395098 - 648 WP_003095021.1 carbonate dehydratase -
EJN51_RS25585 5395160..5396398 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T286271 WP_003117425.1 NZ_LR130537:c5391824-5391546 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT286271 WP_003113527.1 NZ_LR130537:c5391534-5391229 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References