Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5391205..5391800 Replicon chromosome
Accession NZ_LR130536
Organism Pseudomonas aeruginosa isolate paerg010

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag EJ099_RS25565 Protein ID WP_003117425.1
Coordinates 5391522..5391800 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EJ099_RS25560 Protein ID WP_003113527.1
Coordinates 5391205..5391510 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ099_RS25525 5386289..5386576 - 288 WP_088130743.1 DUF5447 family protein -
EJ099_RS25530 5386752..5387024 - 273 WP_004352675.1 hypothetical protein -
EJ099_RS25540 5387471..5387806 + 336 WP_079262960.1 hypothetical protein -
EJ099_RS25545 5387818..5388489 - 672 WP_125075348.1 hypothetical protein -
EJ099_RS25550 5388491..5389618 - 1128 WP_125075349.1 hypothetical protein -
EJ099_RS25555 5389611..5390588 - 978 WP_125080763.1 hypothetical protein -
EJ099_RS25560 5391205..5391510 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
EJ099_RS25565 5391522..5391800 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJ099_RS25575 5392129..5394357 + 2229 WP_003113525.1 TonB-dependent receptor -
EJ099_RS25580 5394427..5395074 - 648 WP_003095021.1 carbonate dehydratase -
EJ099_RS25585 5395136..5396374 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T286266 WP_003117425.1 NZ_LR130536:c5391800-5391522 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT286266 WP_003113527.1 NZ_LR130536:c5391510-5391205 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References