Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2470137..2470912 Replicon chromosome
Accession NZ_LR130534
Organism Pseudomonas aeruginosa isolate paerg005

Toxin (Protein)


Gene name yhaV Uniprot ID V6ADY6
Locus tag EJN62_RS11855 Protein ID WP_009518525.1
Coordinates 2470454..2470912 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A1L1PS41
Locus tag EJN62_RS11850 Protein ID WP_009518526.1
Coordinates 2470137..2470454 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN62_RS11840 2465271..2467922 + 2652 WP_125075549.1 excinuclease ABC subunit UvrA -
EJN62_RS11845 2468000..2469838 - 1839 WP_125075550.1 TraI domain-containing protein -
EJN62_RS11850 2470137..2470454 + 318 WP_009518526.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
EJN62_RS11855 2470454..2470912 + 459 WP_009518525.1 type II toxin-antitoxin system YhaV family toxin Toxin
EJN62_RS11860 2470939..2471316 + 378 WP_009518524.1 DUF3742 family protein -
EJN62_RS11865 2471332..2472849 - 1518 WP_009518523.1 conjugal transfer protein TraG N-terminal domain-containing protein -
EJN62_RS11870 2472864..2473223 - 360 WP_009518522.1 hypothetical protein -
EJN62_RS11875 2473220..2474614 - 1395 WP_009518521.1 integrating conjugative element protein -
EJN62_RS11880 2474624..2475571 - 948 WP_009518520.1 TIGR03756 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2442353..2528671 86318


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(8-144)

Antitoxin

PrlF antitoxin

(8-100)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17660.02 Da        Isoelectric Point: 10.1848

>T286251 WP_009518525.1 NZ_LR130534:2470454-2470912 [Pseudomonas aeruginosa]
MQRHGWTLLFHDCVIEQLQKLHAAARRAQENDPAGFESNANVKLFRALSQLMLDVVPGDPARDEYRQGNTLGPAHRHWRR
AKIGRRFRLFFRYDSKAKVIVYAWVNDEQTLRSSGSKSDPYVVFEKMLGRGNPPDDWHALIQASKQDWSKLE

Download         Length: 459 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11156.69 Da        Isoelectric Point: 4.7182

>AT286251 WP_009518526.1 NZ_LR130534:2470137-2470454 [Pseudomonas aeruginosa]
MPAIHEVATLTSKGQVTLPKPIRQALGVDAGGKLAFDLRGSEVVVTRVDAEHEDPAIGAFLSLLARDIEAGRNVRGLPED
LARAMLEHAGHGVNLDEEIDGKVEL

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ADY6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L1PS41

References