286231

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3004191..3004693 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EJK95_RS14785 Protein ID WP_000767829.1
Coordinates 3004191..3004445 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EJK95_RS14790 Protein ID WP_001259255.1
Coordinates 3004442..3004693 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS14755 2999211..2999438 - 228 WP_000985278.1 sulfurtransferase TusA family protein -
EJK95_RS14760 2999452..3000510 - 1059 WP_000492312.1 transport protein YeeE -
EJK95_RS14765 3000684..3002042 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EJK95_RS14770 3002032..3002094 - 63 WP_010723108.1 membrane protein YoeI -
EJK95_RS14775 3002309..3003238 - 930 WP_023356486.1 LysR family transcriptional regulator -
EJK95_RS14780 3003284..3004108 - 825 WP_000754737.1 SDR family oxidoreductase -
EJK95_RS14785 3004191..3004445 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EJK95_RS14790 3004442..3004693 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EJK95_RS14795 3004976..3005026 + 51 WP_001364200.1 his operon leader peptide -
EJK95_RS14800 3005172..3006071 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
EJK95_RS14805 3006077..3007381 + 1305 WP_001369878.1 histidinol dehydrogenase -
EJK95_RS14810 3007378..3008448 + 1071 WP_000108962.1 histidinol-phosphate transaminase -
EJK95_RS14815 3008448..3009515 + 1068 WP_023356487.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T286231 WP_000767829.1 NZ_LR130532:c3004445-3004191 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT286231 WP_001259255.1 NZ_LR130532:c3004693-3004442 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References