Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3004191..3004693 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EJK95_RS14785 Protein ID WP_000767829.1
Coordinates 3004191..3004445 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EJK95_RS14790 Protein ID WP_001259255.1
Coordinates 3004442..3004693 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS14755 2999211..2999438 - 228 WP_000985278.1 sulfurtransferase TusA family protein -
EJK95_RS14760 2999452..3000510 - 1059 WP_000492312.1 transport protein YeeE -
EJK95_RS14765 3000684..3002042 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EJK95_RS14770 3002032..3002094 - 63 WP_010723108.1 membrane protein YoeI -
EJK95_RS14775 3002309..3003238 - 930 WP_023356486.1 LysR family transcriptional regulator -
EJK95_RS14780 3003284..3004108 - 825 WP_000754737.1 SDR family oxidoreductase -
EJK95_RS14785 3004191..3004445 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EJK95_RS14790 3004442..3004693 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EJK95_RS14795 3004976..3005026 + 51 WP_001364200.1 his operon leader peptide -
EJK95_RS14800 3005172..3006071 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
EJK95_RS14805 3006077..3007381 + 1305 WP_001369878.1 histidinol dehydrogenase -
EJK95_RS14810 3007378..3008448 + 1071 WP_000108962.1 histidinol-phosphate transaminase -
EJK95_RS14815 3008448..3009515 + 1068 WP_023356487.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T286231 WP_000767829.1 NZ_LR130532:c3004445-3004191 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT286231 WP_001259255.1 NZ_LR130532:c3004693-3004442 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References