Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1008433..1008974 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag EJK95_RS04785 Protein ID WP_000615976.1
Coordinates 1008433..1008711 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag EJK95_RS04790 Protein ID WP_000729704.1
Coordinates 1008714..1008974 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS04770 1006015..1006593 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
EJK95_RS04775 1006799..1007566 + 768 WP_000333380.1 class II glutamine amidotransferase -
EJK95_RS04780 1007537..1008277 - 741 WP_001225679.1 murein L,D-transpeptidase -
EJK95_RS04785 1008433..1008711 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EJK95_RS04790 1008714..1008974 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EJK95_RS04795 1009160..1009933 + 774 WP_000543899.1 C40 family peptidase -
EJK95_RS04800 1009990..1010346 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
EJK95_RS04805 1010339..1010617 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
EJK95_RS04810 1010722..1012434 - 1713 Protein_901 flagellar biosynthesis protein FlhA -
EJK95_RS04815 1012406..1013191 + 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T286217 WP_000615976.1 NZ_LR130532:c1008711-1008433 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT286217 WP_000729704.1 NZ_LR130532:c1008974-1008714 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References