Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2708925..2709520 Replicon chromosome
Accession NZ_LR130531
Organism Pseudomonas aeruginosa isolate paerg004

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag EJM92_RS12730 Protein ID WP_003117425.1
Coordinates 2709242..2709520 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EJM92_RS12725 Protein ID WP_003113527.1
Coordinates 2708925..2709230 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJM92_RS12690 2704011..2704298 - 288 WP_088130743.1 DUF5447 family protein -
EJM92_RS12695 2704474..2704746 - 273 WP_004352675.1 hypothetical protein -
EJM92_RS12705 2705193..2705528 + 336 WP_079262960.1 hypothetical protein -
EJM92_RS12710 2705540..2706211 - 672 WP_125075348.1 hypothetical protein -
EJM92_RS12715 2706213..2707340 - 1128 WP_125075349.1 hypothetical protein -
EJM92_RS12720 2707409..2708308 - 900 WP_125075350.1 hypothetical protein -
EJM92_RS12725 2708925..2709230 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
EJM92_RS12730 2709242..2709520 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJM92_RS12740 2709849..2712077 + 2229 WP_003113525.1 TonB-dependent receptor -
EJM92_RS12745 2712147..2712794 - 648 WP_003095021.1 carbonate dehydratase -
EJM92_RS12750 2712856..2714094 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T286210 WP_003117425.1 NZ_LR130531:c2709520-2709242 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT286210 WP_003113527.1 NZ_LR130531:c2709230-2708925 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References