Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1566430..1567025 Replicon chromosome
Accession NZ_LR130528
Organism Pseudomonas aeruginosa isolate paerg000

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag EJN10_RS07470 Protein ID WP_003117425.1
Coordinates 1566430..1566708 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EJN10_RS07475 Protein ID WP_003113527.1
Coordinates 1566720..1567025 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN10_RS07450 1561856..1563094 + 1239 WP_003113524.1 dipeptidase -
EJN10_RS07455 1563156..1563803 + 648 WP_003095021.1 carbonate dehydratase -
EJN10_RS07460 1563873..1566101 - 2229 WP_003113525.1 TonB-dependent receptor -
EJN10_RS07470 1566430..1566708 + 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJN10_RS07475 1566720..1567025 + 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
EJN10_RS07485 1567431..1568531 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
EJN10_RS07490 1568572..1569156 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
EJN10_RS07495 1569198..1569812 - 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
EJN10_RS07500 1569929..1570870 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
EJN10_RS07510 1571037..1571885 - 849 WP_023114865.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T286198 WP_003117425.1 NZ_LR130528:1566430-1566708 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT286198 WP_003113527.1 NZ_LR130528:1566720-1567025 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References