286194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2071810..2072405 Replicon chromosome
Accession NZ_LR130527
Organism Pseudomonas aeruginosa isolate paerg002

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag EJN50_RS10000 Protein ID WP_003117425.1
Coordinates 2072127..2072405 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EJN50_RS09995 Protein ID WP_003113527.1
Coordinates 2071810..2072115 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN50_RS09960 2066894..2067181 - 288 WP_088130743.1 DUF5447 family protein -
EJN50_RS09965 2067357..2067629 - 273 WP_004352675.1 hypothetical protein -
EJN50_RS09975 2068076..2068411 + 336 WP_079262960.1 hypothetical protein -
EJN50_RS09980 2068423..2069094 - 672 WP_125075348.1 hypothetical protein -
EJN50_RS09985 2069096..2070223 - 1128 WP_125075349.1 hypothetical protein -
EJN50_RS09990 2070216..2071193 - 978 WP_125080763.1 hypothetical protein -
EJN50_RS09995 2071810..2072115 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
EJN50_RS10000 2072127..2072405 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJN50_RS10010 2072734..2074962 + 2229 WP_003113525.1 TonB-dependent receptor -
EJN50_RS10015 2075032..2075679 - 648 WP_003095021.1 carbonate dehydratase -
EJN50_RS10020 2075741..2076979 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T286194 WP_003117425.1 NZ_LR130527:c2072405-2072127 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT286194 WP_003113527.1 NZ_LR130527:c2072115-2071810 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References