Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2604486..2605009 Replicon chromosome
Accession NZ_LR130518
Organism Staphylococcus aureus strain BPH2986 isolate BPH2986

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EW031_RS13865 Protein ID WP_000074048.1
Coordinates 2604486..2604752 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag EW031_RS13870 Protein ID WP_000587616.1
Coordinates 2604752..2605009 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW031_RS13845 2599793..2600980 - 1188 WP_000026194.1 MFS transporter -
EW031_RS13850 2601376..2602152 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
EW031_RS13855 2602145..2602807 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
EW031_RS13860 2603055..2604131 - 1077 WP_001076671.1 M42 family metallopeptidase -
EW031_RS13865 2604486..2604752 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EW031_RS13870 2604752..2605009 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW031_RS13880 2605368..2605823 + 456 WP_000732082.1 DUF1307 domain-containing protein -
EW031_RS13885 2605991..2607568 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
EW031_RS13890 2607763..2608512 + 750 WP_000072444.1 hypothetical protein -
EW031_RS13895 2608736..2609929 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286191 WP_000074048.1 NZ_LR130518:c2604752-2604486 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286191 WP_000587616.1 NZ_LR130518:c2605009-2604752 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References