Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2547638..2548155 Replicon chromosome
Accession NZ_LR130518
Organism Staphylococcus aureus strain BPH2986 isolate BPH2986

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag EW031_RS13545 Protein ID WP_000113262.1
Coordinates 2547638..2547904 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag EW031_RS13550 Protein ID WP_000584502.1
Coordinates 2547904..2548155 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW031_RS13515 2543064..2543600 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
EW031_RS13520 2543833..2544657 - 825 WP_000572040.1 formate/nitrite transporter family protein -
EW031_RS13525 2544874..2545056 - 183 WP_000230294.1 hypothetical protein -
EW031_RS13530 2545140..2545607 - 468 WP_000153344.1 SRPBCC domain-containing protein -
EW031_RS13535 2545793..2547343 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EW031_RS13540 2547532..2547603 - 72 Protein_2506 hypothetical protein -
EW031_RS13545 2547638..2547904 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
EW031_RS13550 2547904..2548155 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW031_RS13555 2548320..2548421 - 102 WP_001791744.1 hypothetical protein -
EW031_RS13560 2548428..2549027 - 600 WP_000162813.1 DsbA family protein -
EW031_RS13565 2549046..2549405 - 360 WP_000819847.1 DUF4467 domain-containing protein -
EW031_RS13570 2549660..2550910 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
EW031_RS13575 2551007..2551738 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EW031_RS13580 2551735..2552454 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286189 WP_000113262.1 NZ_LR130518:c2547904-2547638 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT286189 WP_000584502.1 NZ_LR130518:c2548155-2547904 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References