Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2108197..2108496 Replicon chromosome
Accession NZ_LR130518
Organism Staphylococcus aureus strain BPH2986 isolate BPH2986

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag EW031_RS11100 Protein ID WP_011447039.1
Coordinates 2108320..2108496 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2108197..2108252 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW031_RS11055 2103528..2103788 + 261 WP_001791826.1 hypothetical protein -
EW031_RS11060 2103841..2104191 - 351 WP_000702263.1 complement inhibitor SCIN-A -
EW031_RS11065 2104876..2105325 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
EW031_RS11070 2105420..2105755 - 336 Protein_2042 SH3 domain-containing protein -
EW031_RS11080 2106405..2106896 - 492 WP_000919350.1 staphylokinase -
EW031_RS11085 2107087..2107842 - 756 WP_129790285.1 CHAP domain-containing protein -
EW031_RS11090 2107854..2108108 - 255 WP_000611512.1 phage holin -
EW031_RS11095 2108160..2108267 + 108 WP_001791821.1 hypothetical protein -
- 2108189..2108328 + 140 NuclAT_0 - -
- 2108189..2108328 + 140 NuclAT_0 - -
- 2108189..2108328 + 140 NuclAT_0 - -
- 2108189..2108328 + 140 NuclAT_0 - -
- 2108197..2108252 + 56 - - Antitoxin
EW031_RS11100 2108320..2108496 - 177 WP_011447039.1 putative holin-like toxin Toxin
EW031_RS11105 2108646..2108942 - 297 WP_000539688.1 DUF2951 domain-containing protein -
EW031_RS11110 2109000..2109287 - 288 WP_001040261.1 hypothetical protein -
EW031_RS11115 2109334..2109486 - 153 WP_001153681.1 hypothetical protein -
EW031_RS11120 2109476..2113261 - 3786 WP_000582165.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 2103841..2159790 55949


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T286182 WP_011447039.1 NZ_LR130518:c2108496-2108320 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT286182 NZ_LR130518:2108197-2108252 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References