286178

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2744495..2745018 Replicon chromosome
Accession NZ_LR130515
Organism Staphylococcus aureus strain BPH2947 isolate BPH2947

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EW033_RS14595 Protein ID WP_000074048.1
Coordinates 2744495..2744761 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag EW033_RS14600 Protein ID WP_000587616.1
Coordinates 2744761..2745018 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW033_RS14575 2739802..2740989 - 1188 WP_000026194.1 MFS transporter -
EW033_RS14580 2741385..2742161 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
EW033_RS14585 2742154..2742816 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
EW033_RS14590 2743064..2744140 - 1077 WP_001076671.1 M42 family metallopeptidase -
EW033_RS14595 2744495..2744761 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EW033_RS14600 2744761..2745018 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW033_RS14605 2745124..2745318 - 195 WP_001790145.1 hypothetical protein -
EW033_RS14610 2745377..2745832 + 456 WP_000732080.1 DUF1307 domain-containing protein -
EW033_RS14615 2746000..2747577 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
EW033_RS14620 2747772..2748521 + 750 WP_000072442.1 hypothetical protein -
EW033_RS14625 2748745..2749938 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286178 WP_000074048.1 NZ_LR130515:c2744761-2744495 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286178 WP_000587616.1 NZ_LR130515:c2745018-2744761 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References