Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2687644..2688161 Replicon chromosome
Accession NZ_LR130515
Organism Staphylococcus aureus strain BPH2947 isolate BPH2947

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag EW033_RS14280 Protein ID WP_000113262.1
Coordinates 2687644..2687910 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EW033_RS14285 Protein ID WP_000584499.1
Coordinates 2687910..2688161 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW033_RS14250 2683070..2683606 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
EW033_RS14255 2683839..2684663 - 825 WP_000572040.1 formate/nitrite transporter family protein -
EW033_RS14260 2684880..2685062 - 183 WP_000230294.1 hypothetical protein -
EW033_RS14265 2685146..2685613 - 468 WP_000153344.1 SRPBCC domain-containing protein -
EW033_RS14270 2685799..2687349 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EW033_RS14275 2687538..2687609 - 72 Protein_2650 hypothetical protein -
EW033_RS14280 2687644..2687910 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
EW033_RS14285 2687910..2688161 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW033_RS14290 2688326..2688427 - 102 WP_001791744.1 hypothetical protein -
EW033_RS14295 2688434..2689033 - 600 WP_000162813.1 DsbA family protein -
EW033_RS14300 2689052..2689414 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EW033_RS14305 2689669..2690919 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
EW033_RS14310 2691016..2691747 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EW033_RS14315 2691744..2692463 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286176 WP_000113262.1 NZ_LR130515:c2687910-2687644 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286176 WP_000584499.1 NZ_LR130515:c2688161-2687910 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References