Detailed information of TA system TA286175

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2422633..2422850
• Replicon: chromosome
• Accession: NZ_LR130515
• Organism: Staphylococcus aureus strain BPH2947 isolate BPH2947

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: EW033_RS12850
• Protein ID: WP_001802298.1
• Coordinates: 2422746..2422850 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2422633..2422688 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW033_RS12830	2418770..2419435	-	666	WP_001024094.1	SDR family oxidoreductase	-
EW033_RS12835	2419587..2419907	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
EW033_RS12840	2419909..2420889	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
EW033_RS12845	2421155..2422246	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2422633..2422688	+	56	-	-	Antitoxin
EW033_RS12850	2422746..2422850	-	105	WP_001802298.1	hypothetical protein	Toxin
EW033_RS16315	2423011..2423494	-	484	Protein_2384	recombinase family protein	-
EW033_RS12860	2423537..2424673	-	1137	WP_000115564.1	SAP domain-containing protein	-
EW033_RS12865	2424962..2425054	+	93	WP_001790138.1	hypothetical protein	-
EW033_RS12870	2425759..2426616	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
EW033_RS12875	2426684..2427466	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T286175 WP_001802298.1 NZ_LR130515:c2422850-2422746 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT286175 NZ_LR130515:2422633-2422688 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin