Detailed information of TA system TA286166

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2118363..2118662
• Replicon: chromosome
• Accession: NZ_LR130515
• Organism: Staphylococcus aureus strain BPH2947 isolate BPH2947

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: EW033_RS11065
• Protein ID: WP_072482930.1
• Coordinates: 2118486..2118662 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2118363..2118418 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW033_RS11010	2113921..2114100	+	180	WP_000669789.1	hypothetical protein	-
EW033_RS11020	2114411..2114671	+	261	WP_001791826.1	hypothetical protein	-
EW033_RS11025	2114724..2115074	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
EW033_RS11030	2115584..2115919	-	336	Protein_2032	SH3 domain-containing protein	-
EW033_RS11045	2116571..2117062	-	492	WP_000920041.1	staphylokinase	-
EW033_RS11050	2117253..2118008	-	756	WP_000861038.1	CHAP domain-containing protein	-
EW033_RS11055	2118020..2118274	-	255	WP_000611512.1	phage holin	-
EW033_RS11060	2118326..2118433	+	108	Protein_2036	hypothetical protein	-
-	2118355..2118494	+	140	NuclAT_0	-	-
-	2118355..2118494	+	140	NuclAT_0	-	-
-	2118355..2118494	+	140	NuclAT_0	-	-
-	2118355..2118494	+	140	NuclAT_0	-	-
-	2118363..2118418	+	56	-	-	Antitoxin
EW033_RS11065	2118486..2118662	-	177	WP_072482930.1	putative holin-like toxin	Toxin
EW033_RS11070	2118771..2119544	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
EW033_RS11075	2119917..2120291	-	375	WP_000340977.1	hypothetical protein	-
EW033_RS11080	2120347..2120634	-	288	WP_001262621.1	hypothetical protein	-
EW033_RS11085	2120680..2120832	-	153	WP_001000059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2114724..2172248	57524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T286166 WP_072482930.1 NZ_LR130515:c2118662-2118486 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT286166 NZ_LR130515:2118363-2118418 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin