Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2536598..2537121 Replicon chromosome
Accession NZ_LR130513
Organism Staphylococcus aureus strain BPH2900 isolate BPH2900

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EW029_RS13085 Protein ID WP_000074048.1
Coordinates 2536598..2536864 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag EW029_RS13090 Protein ID WP_000587616.1
Coordinates 2536864..2537121 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW029_RS13065 2531809..2532996 - 1188 WP_000026196.1 MFS transporter -
EW029_RS13070 2533390..2534166 - 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
EW029_RS13075 2534159..2534821 - 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
EW029_RS13080 2535167..2536243 - 1077 WP_001076688.1 M42 family metallopeptidase -
EW029_RS13085 2536598..2536864 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EW029_RS13090 2536864..2537121 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW029_RS13100 2537480..2537935 + 456 WP_000732088.1 DUF1307 domain-containing protein -
EW029_RS13105 2538103..2539680 - 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
EW029_RS13110 2539875..2540624 + 750 WP_000072439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286161 WP_000074048.1 NZ_LR130513:c2536864-2536598 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286161 WP_000587616.1 NZ_LR130513:c2537121-2536864 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References