Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2478591..2479108 Replicon chromosome
Accession NZ_LR130513
Organism Staphylococcus aureus strain BPH2900 isolate BPH2900

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EW029_RS12780 Protein ID WP_000113261.1
Coordinates 2478591..2478857 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EW029_RS12785 Protein ID WP_000584499.1
Coordinates 2478857..2479108 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW029_RS12755 2474028..2474564 - 537 WP_000169319.1 GNAT family N-acetyltransferase -
EW029_RS12760 2474798..2475622 - 825 WP_000594637.1 formate/nitrite transporter family protein -
EW029_RS12765 2475825..2476007 - 183 WP_000250735.1 hypothetical protein -
EW029_RS12770 2476094..2476561 - 468 WP_000153345.1 SRPBCC domain-containing protein -
EW029_RS12775 2476747..2478297 - 1551 WP_000727760.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EW029_RS12780 2478591..2478857 - 267 WP_000113261.1 Txe/YoeB family addiction module toxin Toxin
EW029_RS12785 2478857..2479108 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW029_RS12790 2479271..2479372 - 102 Protein_2387 hypothetical protein -
EW029_RS12795 2479379..2479978 - 600 WP_000162810.1 DsbA family protein -
EW029_RS12800 2479997..2480359 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EW029_RS12805 2480614..2481864 + 1251 WP_001012231.1 FemA/FemB family glycyltransferase FmhA -
EW029_RS12810 2481949..2482680 - 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
EW029_RS12815 2482677..2483396 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10452.02 Da        Isoelectric Point: 10.0373

>T286159 WP_000113261.1 NZ_LR130513:c2478857-2478591 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Download         Length: 267 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286159 WP_000584499.1 NZ_LR130513:c2479108-2478857 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References