Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF2/-
Location 2038227..2038526 Replicon chromosome
Accession NZ_LR130513
Organism Staphylococcus aureus strain BPH2900 isolate BPH2900

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag EW029_RS10340 Protein ID WP_011447039.1
Coordinates 2038350..2038526 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2038227..2038282 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW029_RS10295 2033558..2033818 + 261 WP_001791826.1 hypothetical protein -
EW029_RS10300 2033871..2034221 - 351 WP_000702263.1 complement inhibitor SCIN-A -
EW029_RS10305 2034906..2035355 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
EW029_RS10310 2035450..2035785 - 336 Protein_1920 SH3 domain-containing protein -
EW029_RS10320 2036435..2036926 - 492 WP_000919349.1 staphylokinase -
EW029_RS10325 2037117..2037872 - 756 WP_000861038.1 CHAP domain-containing protein -
EW029_RS10330 2037884..2038138 - 255 WP_000611512.1 phage holin -
EW029_RS10335 2038190..2038297 + 108 WP_001791821.1 hypothetical protein -
- 2038219..2038358 + 140 NuclAT_1 - -
- 2038219..2038358 + 140 NuclAT_1 - -
- 2038219..2038358 + 140 NuclAT_1 - -
- 2038219..2038358 + 140 NuclAT_1 - -
- 2038227..2038282 + 56 - - Antitoxin
EW029_RS10340 2038350..2038526 - 177 WP_011447039.1 putative holin-like toxin Toxin
EW029_RS10345 2038676..2038972 - 297 WP_000539688.1 DUF2951 domain-containing protein -
EW029_RS10350 2039030..2039317 - 288 WP_001040261.1 hypothetical protein -
EW029_RS10355 2039364..2039516 - 153 WP_001153681.1 hypothetical protein -
EW029_RS10360 2039506..2043291 - 3786 WP_000582168.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL / hld 2033871..2113111 79240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T286154 WP_011447039.1 NZ_LR130513:c2038526-2038350 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT286154 NZ_LR130513:2038227-2038282 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References