Detailed information of TA system TA286153

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2038219..2038526
• Replicon: chromosome
• Accession: NZ_LR130513
• Organism: Staphylococcus aureus strain BPH2900 isolate BPH2900

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EW029_RS10340
• Protein ID: WP_011447039.1
• Coordinates: 2038350..2038526 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2038219..2038358 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW029_RS10295	2033558..2033818	+	261	WP_001791826.1	hypothetical protein	-
EW029_RS10300	2033871..2034221	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
EW029_RS10305	2034906..2035355	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
EW029_RS10310	2035450..2035785	-	336	Protein_1920	SH3 domain-containing protein	-
EW029_RS10320	2036435..2036926	-	492	WP_000919349.1	staphylokinase	-
EW029_RS10325	2037117..2037872	-	756	WP_000861038.1	CHAP domain-containing protein	-
EW029_RS10330	2037884..2038138	-	255	WP_000611512.1	phage holin	-
EW029_RS10335	2038190..2038297	+	108	WP_001791821.1	hypothetical protein	-
-	2038219..2038358	+	140	NuclAT_1	-	Antitoxin
-	2038219..2038358	+	140	NuclAT_1	-	Antitoxin
-	2038219..2038358	+	140	NuclAT_1	-	Antitoxin
-	2038219..2038358	+	140	NuclAT_1	-	Antitoxin
EW029_RS10340	2038350..2038526	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EW029_RS10345	2038676..2038972	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
EW029_RS10350	2039030..2039317	-	288	WP_001040261.1	hypothetical protein	-
EW029_RS10355	2039364..2039516	-	153	WP_001153681.1	hypothetical protein	-
EW029_RS10360	2039506..2043291	-	3786	WP_000582168.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL / hld	2033871..2113111	79240

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T286153 WP_011447039.1 NZ_LR130513:c2038526-2038350 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT286153 NZ_LR130513:2038219-2038358 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin